Celtic are out of the Champions League, despite staging a late rally against AEK Athens in Greece.
The Scottish side were two down after 50 minutes of the second leg through goals by Rodrigo Galo and Marko Livaja.
And although Scott Sinclair’s header gave Celtic hope, the Greeks held firm in the third qualifying round tie.
The defeat consigns Brendan Rodgers side to a Europa League play-off round meeting with Latvia’s Spartaks Jurmala or Suduva Marijampole of Lithuania.
Suduva hold a 1-0 lead and an away goal advantage going into Thursday’s third qualifying round deciding leg.
AEK, meanwhile, will play Hungarian outfit MOL Vidi in the Champions League play-off round.
Defensive frailties cost Celtic
The preamble to the match had been dominated by headlines about Dedryck Boyata’s Celtic future. But without the Belgian international and the suspended Kristoffer Ajer, Rodgers was left with Jack Hendry and the returning Jozo Simunovic as his central defensive pairing.
That weakened rearguard was a concern and, as was feared, it was opened up within six minutes. Nicklas Hult pulled back a pass to find Rodrigo in too much space to apply a finish from 14 yards.
Celtic did settle after that discombobulating start, enjoying plenty of the ball, but chances were scarce as Rodgers’ side searched for the required away goal.
Leigh Griffiths led the attack – with record signing Odsonne Edouard injured and Moussa Dembele on the bench – and the Scotland forward latched on to Callum McGregor’s teasing delivery only to steer wide under duress from his marker.
Celtic were being allowed to push forward by an Athens side content to wait for the right moment to try and put the result beyond doubt. And that moment came just after the break, Vassilis Lambropoulos outjumping Hendry to meet Rodrigo’s set piece and direct across the six-yard box for Livaja to nod in.
That left the Scottish champions in a desperate predicament as they scrambled to get back into the tie.
Simunovic’s glancing header and Olivier Ntcham’s free-kick were both well saved by Vasilios Barkas, but Sinclair reduced the deficit with 12 minutes remaining when headed in Kieran Tierney’s cross.
Another goal would have secured a win on away goals. Celtic pushed forward. AEK grew edgy.
In the fifth and final minute of added time the chance came. But Simunovic’s flicked cross from McGregor’s ball flew inches past a post. And seconds later, the home side were celebrating.
‘Rodgers saw the signs’ – analysis
BBC Scotland’s senior football reporter Chris McLaughlin in Athens
This was coming. Rodgers did everything but spell it out over the past few weeks. He is a man who constantly talks about progress and for the first time since his arrival, the club is going backwards in European football. He saw the signs, made the noises, but all in vain.
It was no thumping. The fact is was close will frustrate the Celtic manager all the more. Who knows what difference a couple of new faces may have made for a Celtic side who looked devoid of ideas at times over the two legs. At this level, and given where they have been for the past two years, the margins are fine. That will keep Rodgers awake for the next few nights.
The Europa League is little consolation, both in a football and a financial sense but that is where they find themselves. Fans might attempt to soothe the pain with thoughts of a lengthy run in European football’s booby prize, but unless Celtic sort out the on and off-field issues, that seems fanciful.
Those who refused to believe that cracks were showing, might do well to look again. The manager has said he is going nowhere, now he must fight to arrest a worrying slide.