The Spanish side come into the match on the back of two draws and a victory in LaLiga as they attempt to wrap up the title in their homeland, with their closest competition seven points away.
And on the back of an unbeaten group stage campaign in the Champions League, manager Ernesto Valverde will be confident of success against the Blues.
Tactically, the Spaniard has both a 4-4-2 and a 4-3-3 at his disposal but, with Philippe Coutinho cup-tied and Ousmane Dembele only just returning from injury, the former formation is currently more likely.
They are also without Nelson Semedo through suspension, while Thomas Vermaelen travelled but is a doubt for the match.
So, who will Valverde pick for the huge Champions League match?
Click the right arrow above to find out our predicted Barcelona XI to face Chelsea…